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Tuesday, November 3rd, 2009
|Paging Mrs. Frisby
http://www.hplusmagazine.com/articles/neuro/making-smarter-ratAccording to Science Daily, Hobbie-J was able to remember novel objects, such as a toy she played with, three times longer than the average Long Evans female rat, the smartest rat strain. Hobbie-J was also better at remembering which path she last traveled to find a chocolate treat.
Researchers from the Medical College of Georgia and East China Normal University developed Hobbie-J 's superior brainpower by transgenic over-expression of the NR2B gene, which in turn increased communication between NMDA receptor sites maybe a hundred milliseconds longer than normal, just enough to enhance learning and memory. NMDA receptors (and their NR2B subunits) are the controlling molecular structures for synaptic plasticity and memory.